Oral Administration of Heat-Killed Lactobacillus plantarum Strain b240 Protected Mice against Salmonella enterica Serovar Typhimurium

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  • ISHIKAWA Hiroki
    Department of Microbiology, Tokyo Medical University
  • KUTSUKAKE Etsuko
    Department of Microbiology, Tokyo Medical University
  • FUKUI Toshie
    Department of Microbiology, Tokyo Medical University
  • SATO Ikutaro
    Otsu Nutraceuticals Research Institute, Otsuka Pharmaceutical Co., Ltd.
  • SHIRAI Toshiaki
    Department of Microbiology, Tokyo Medical University Department of Biosciences, Teikyo University of Science and Technology
  • KURIHARA Tatsuya
    Department of Microbiology, Tokyo Medical University Department of Biosciences, Teikyo University of Science and Technology
  • OKADA Nobuhiko
    Department of Microbiology, School of Pharmaceutical Science, Kitasato University
  • DANBARA Hirofumi
    Department of Microbiology, School of Pharmaceutical Science, Kitasato University
  • TOBA Masamichi
    Otsu Nutraceuticals Research Institute, Otsuka Pharmaceutical Co., Ltd.
  • KOHDA Noriyuki
    Otsu Nutraceuticals Research Institute, Otsuka Pharmaceutical Co., Ltd.
  • MAEDA Yasuyuki
    Department of Biosciences, Teikyo University of Science and Technology
  • MATSUMOTO Tetsuya
    Department of Microbiology, Tokyo Medical University

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  • Oral Administration of Heat-Killed<i>Lactobacillus plantarum</i>Strain b240 Protected Mice against<i>Salmonella enterica</i>Serovar Typhimurium

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The purpose of this study was to investigate the effects of heat-killed Lactobacillus plantarum strain b240 (b240) on systemic infection by Salmonella enterica serovar Typhimurium (S. Typhimurium) and to determine the mechanism by which b240 protects against infection. Mice were administered either b240 or saline orally for 3 weeks, and then inoculated with S. Typhimurium. The mice treated with b240 were significantly protected against S. Typhimurium as compared to those fed saline. Moreover, translocation of S. Typhimurium into each organ tested in the mice that received b240 tended to be less than in the control mice. An important mechanism of protection against infection was demonstrated by the ability of b240 to inhibit both binding by and invasion of S. Typhimurium into cells. These results indicate that nonviable lactic acid bacteria also play important roles in preventing infection by enteric pathogens.

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