Reduction of Blood Pressure by Soybean Saponins, Renin Inhibitors from Soybean, in Spontaneously Hypertensive Rats
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- HIWATASHI Kazuyuki
- Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University Akita Research Institute of Food and Brewing
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- SHIRAKAWA Hitoshi
- Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University
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- HORI Kazuyuki
- Akita Research Institute of Food and Brewing
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- YOSHIKI Yumiko
- Department of Food Science, Ishikawa Prefectural University
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- SUZUKI Nao
- Akita Research Institute of Food and Brewing
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- HOKARI Mika
- Akita Research Institute of Food and Brewing
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- KOMAI Michio
- Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University
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- TAKAHASHI Saori
- Akita Research Institute of Food and Brewing
Bibliographic Information
- Other Title
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- Reduction of blood pressure by soybean saponins, rennin inhibitors from soybean, in spontaneously hypertensive rats
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Abstract
The effect of commercial purified soybean saponin on renin activity and blood pressure was investigated. Soybean saponin significantly inhibited human renin in vitro with IC50=59.9 μg/ml. Orally administered soybean saponin at 80 mg/kg of body weight per day to spontaneously hypertensive rats for 8 weeks significantly decreased the blood pressure.
Journal
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 74 (11), 2310-2312, 2010
Japan Society for Bioscience, Biotechnology, and Agrochemistry
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Details 詳細情報について
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- CRID
- 1390282681456103168
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- NII Article ID
- 10027561804
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- NII Book ID
- AA10824164
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- ISSN
- 13476947
- 09168451
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- NDL BIB ID
- 10899955
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed