Reduction of Blood Pressure by Soybean Saponins, Renin Inhibitors from Soybean, in Spontaneously Hypertensive Rats

  • HIWATASHI Kazuyuki
    Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University Akita Research Institute of Food and Brewing
  • SHIRAKAWA Hitoshi
    Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University
  • HORI Kazuyuki
    Akita Research Institute of Food and Brewing
  • YOSHIKI Yumiko
    Department of Food Science, Ishikawa Prefectural University
  • SUZUKI Nao
    Akita Research Institute of Food and Brewing
  • HOKARI Mika
    Akita Research Institute of Food and Brewing
  • KOMAI Michio
    Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University
  • TAKAHASHI Saori
    Akita Research Institute of Food and Brewing

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  • Reduction of blood pressure by soybean saponins, rennin inhibitors from soybean, in spontaneously hypertensive rats

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Abstract

The effect of commercial purified soybean saponin on renin activity and blood pressure was investigated. Soybean saponin significantly inhibited human renin in vitro with IC50=59.9 μg/ml. Orally administered soybean saponin at 80 mg/kg of body weight per day to spontaneously hypertensive rats for 8 weeks significantly decreased the blood pressure.

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