Cilostazol ameliorates nephropathy in type 1 diabetic rats involving improvement in oxidative stress and regulation of TGF-β and NF-κB

DOI Web Site Web Site PubMed 被引用文献1件 参考文献45件
  • LEE Wen-Chin
    Division of Nephrology, Department of Internal Medicine, Show Chwan Memorial Hospital Department of Life Sciences, National Chung Hsing University Central Taiwan University of Science and Technology
  • CHEN Hong-Chen
    Department of Life Sciences, National Chung Hsing University
  • WANG Chih-Ying
    Institute of Biochemistry and Biotechnology, Medical College, Chung Shan Medical University
  • LIN Pei-Ying
    Institute of Biochemistry and Biotechnology, Medical College, Chung Shan Medical University
  • OU Tin-Tsz
    Institute of Biochemistry and Biotechnology, Medical College, Chung Shan Medical University
  • CHEN Chen-Chang
    Department of Pathology, Taichung Veterans General Hospital
  • WEN Mei-Chin
    Department of Pathology, Taichung Veterans General Hospital
  • WANG John
    Department of Pathology, Taichung Veterans General Hospital
  • LEE Huei-Jane
    Institute of Biochemistry and Biotechnology, Medical College, Chung Shan Medical University Department of Biochemistry, School of Medicine, Chung Shan Medical University Clinical Laboratory, Chung Shan Medical University Hospital

書誌事項

タイトル別名
  • Cilostazol Ameliorates Nephropathy in Type 1 Diabetic Rats Involving Improvement in Oxidative Stress and Regulation of TGF-.BETA. and NF-.KAPPA.B
  • Cilostazol ameliorates nephropathy in type 1 diabetic rats involving improvement in oxidative stress and regulation of TGF v and NF k B

この論文をさがす

抄録

Diabetic nephropathy is characterized as the progressive development of renal insufficiency in a setting of hyperglycemia. Previous studies indicate that reactive oxygen species (ROS) play an important role in high glucose-induced renal injury. Cilostazol was reported to lower the production of superoxide significantly in situ. We hypothesized that cilostazol administration in streptozotocin-induced diabetic rats exerts effects via improving oxidative stress. Male Sprague–Dawley rats were fed with cilostazol (5 mg/kg or 25 mg/kg) for 12 weeks after streptozotocin-induced diabetes mellitus. The results showed that cilostazol decreased reactive oxygen species activity significantly in the kidneys of diabetic rats and improved the urine albumin/creatinine ratio. Cilostazol can also improve the levels of serum cholesterol, triglyceride, and LDL-cholesterol. Additionally, diabetes-caused increased glomerular size, TGF-β, and NF-κB decreased under treatment with cilostazol in diabetic rats. Our results indicate that cilostazol has beneficial effects in early diabetic nephropathy.

収録刊行物

被引用文献 (1)*注記

もっと見る

参考文献 (45)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ