Inhibition of Plasma Hyaluronan-Binding Protein Autoactivation by Laccaic Acid

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  • SEKIDO Chikako
    Department of Applied Biological Science, Tokyo University of Agriculture and Technology
  • NISHIMURA Naoko
    Department of Applied Biological Science, Tokyo University of Agriculture and Technology
  • TAKAI Masayuki
    Department of Applied Biological Science, Tokyo University of Agriculture and Technology
  • HASUMI Keiji
    Department of Applied Biological Science, Tokyo University of Agriculture and Technology

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Abstract

Plasma hyaluronan-binding protein (PHBP) is a serine protease implicated in proteolysis under inflammatory conditions. We identified laccaic acid, a widely used food coloring from scale insects, as a potent inhibitor of the protease in terms of both autoactivation of the PHBP proenzyme (IC50 = 0.35–0.55 μg/ml) and the catalytic activity of the active enzyme (IC50 = 1.1 μg/ml).

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