Complexation of tocotrienol with γ-cyclodextrin enhances intestinal absorption of tocotrienol in rats
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- IKEDA Saiko
- Department of Nutritional Sciences, Nagoya University of Arts and Sciences
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- UCHIDA Tomono
- Department of Nutritional Sciences, Nagoya University of Arts and Sciences
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- ICHIKAWA Tomio
- Department of Nutritional Sciences, Nagoya University of Arts and Sciences
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- WATANABE Takashi
- Oryza Oil & Fat Chemical Co., Ltd.
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- UEKAJI Yukiko
- CycloChem Co., Ltd.
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- NAKATA Daisuke
- CycloChem Co., Ltd.
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- TERAO Keiji
- CycloChem Co., Ltd.
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- YANO Tomohiro
- Project for Complementary Medicine, National Institute of Health and Nutrition
書誌事項
- タイトル別名
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- Complexation of Tocotrienol with .GAMMA.-Cyclodextrin Enhances Intestinal Absorption of Tocotrienol in Rats
- Complexation of tocotrienol with g cyclodextrin enhances intestinal absorption of tocotrienol in rats
この論文をさがす
抄録
To determine the bioavailability of tocotrienol complex with γ-cyclodextrin, the effects of tocotrienol/γ-cyclodextrin complex on tocotrienol concentration in rat plasma and tissues were studied. Rats were administered by oral gavage an emulsion containing tocotrienol, tocotrienol with γ-cyclodextrin, or tocotrienol/γ-cyclodextrin complex. At 3 h after administration, the plasma γ-tocotrienol concentration of the rats administered tocotrienol/γ-cyclodextrin complex was higher than that of the rats administered tocotrienol and γ-cyclodextrin. In order to determine the effect of complexation on tocotrienol absorption, rats were injected with Triton WR1339, which prevents the catabolism of triacylglycerol-rich lipoprotein by lipoprotein lipase, and then administered by oral gavage an emulsion containing tocotrienol, tocotrienol with γ-cyclodextrin, or tocotrienol/γ-cyclodextrin complex. The plasma γ-tocotrienol concentration of the Triton-treated rats administered tocotrienol/γ-cyclodextrin complex was higher than that of the other Triton-treated rats. These results suggest that complexation of tocotrienol with γ-cyclodextrin elevates plasma and tissue tocotrienol concentrations by enhancing intestinal absorption.
収録刊行物
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 74 (7), 1452-1457, 2010
公益社団法人 日本農芸化学会
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詳細情報 詳細情報について
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- CRID
- 1390282681456230272
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- NII論文ID
- 10027557431
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- NII書誌ID
- AA10824164
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- COI
- 1:STN:280:DC%2BC3cjgvFaiug%3D%3D
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- ISSN
- 13476947
- 09168451
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- NDL書誌ID
- 10766678
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- PubMed
- 20622447
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可