Polyphenolic Constituent Structures of Zanthoxylum piperitum Fruit and the Antibacterial Effects of Its Polymeric Procyanidin on Methicillin-Resistant Staphylococcus aureus

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  • KUSUDA Miwako
    Department of Pharmacognosy, Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
  • INADA Kazutoshi
    Department of Pharmacognosy, Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
  • OGAWA Tomo-omi
    Department of Pharmacognosy, Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
  • YOSHIDA Takashi
    Department of Pharmacognosy, Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
  • SHIOTA Sumiko
    Department of Pathogenic Microbiology, School of Pharmacy, Shujitsu University
  • TSUCHIYA Tomofusa
    Department of Microbiology, Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
  • HATANO Tsutomu
    Department of Pharmacognosy, Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

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  • Polyphenolic Constituent Structures of<i>Zanthoxylum piperitum</i>Fruit and the Antibacterial Effects of Its Polymeric Procyanidin on Methicillin-Resistant<i>Staphylococcus aureus</i>
  • Polyphenolic constituent structures of <italic>Zanthoxylum piperitum</italic> fruit and the antibacterial effects of its polymeric procyanidin on methicillin-resistant <italic>Staphylococcus aureus</italic>

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Zanthoxylum piperitum (Rutaceae) is used as a spice and a natural medicine in Japan. Our study found that ZP-CT-A, a polymeric proanthocyanidin purified from the fruit of this species, noticeably decreased the minimum inhibitory concentrations of β-lactam antibiotics for methicillin-resistant Staphylococcus aureus (MRSA). The structure of ZP-CT-A was characterized on the basis of 13C NMR and size exclusion chromatographic data and the results of thiolytic degradation. A mechanistic study of the effects of ZP-CT-A indicated that it suppressed the activity of β-lactamase and largely decreased the stability of the bacterial cell membrane of MRSA, as shown by a reduction in the tolerance of MRSA to low osmotic pressure and high ionic strength solutions.

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