Zinc Depletion Activates the Endoplasmic Reticulum-Stress Sensor Ire1 <i>via</i> Pleiotropic Mechanisms
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- NGUYEN Thanh Sy Le
- Graduate School of Biological Sciences, Nara Institute of Science and Technology
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- KOHNO Kenji
- Graduate School of Biological Sciences, Nara Institute of Science and Technology
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- KIMATA Yukio
- Graduate School of Biological Sciences, Nara Institute of Science and Technology
Bibliographic Information
- Other Title
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- Zinc Depletion Activates the Endoplasmic Reticulum-Stress Sensor Ire1 via Pleiotropic Mechanisms
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Abstract
Although zinc deficiency evokes the endoplasmic reticulum (ER)-stress response, the activating mechanism remains obscure. Here we show that in yeast cells, the ER-stress sensor Ire1 was activated upon zinc deficiency. ER-stressing stimuli activating Ire1 are known to include ER accumulation of unfolded proteins and membrane-lipid aberrancy. According to the findings presented here, zinc deficiency causes both types of abnormality.
Journal
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 77 (6), 1337-1339, 2013
Japan Society for Bioscience, Biotechnology, and Agrochemistry
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Details 詳細情報について
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- CRID
- 1390282681456475904
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- NII Article ID
- 10031184709
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- NII Book ID
- AA10824164
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- COI
- 1:STN:280:DC%2BC3sjhtFWgsQ%3D%3D
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- ISSN
- 13476947
- 09168451
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- NDL BIB ID
- 024647316
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- PubMed
- 23748779
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed