Award Review : Unique Biosynthesis of Sesquarterpenes (C₃₅ Terpenes)
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- SATO Tsutomu
- Department of Applied Biological Chemistry, Faculty of Agriculture and Graduate School of Science and Technology, Niigata University
書誌事項
- タイトル別名
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- Unique Biosynthesis of Sesquarterpenes (C<sub>35</sub> Terpenes)
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To the best of my knowledge, only 19 cyclic and 8 linear C35 terpenes have been identified to date, and no family name was assigned to this terpene class until recently. In 2011, it was proposed that these C35 terpenes should be called sesquarterpenes. This review highlights the biosynthesis of two kinds of sesquarterpenes (C35 terpenes) that are produced via cyclization of a linear C35 isoprenoid in Bacillus and Mycobacterium species. In Bacillus species, a new type of terpene cyclase that has no sequence homology with any known terpene synthases, as well as a bifunctional terpene cyclase that biosynthesizes two classes of cyclic terpenes with different numbers of carbons as natural products, have been identified. On the other hand, in Mycobacterium species, the first bifunctional Z-prenyltransferase has been found, but a novel terpene cyclase and a unique polyprenyl reductase remain unidentified. The identification of novel enzyme types should lead to the discovery of many homologous enzymes and their products including novel natural compounds. On the other hand, many enzymes responsible for the biosynthesis of natural products have low substrate specificities in vitro. Therefore, to find novel natural products present in organisms, the multifunctionality of enzymes in the biosynthetic pathway of natural products should be analyzed.
収録刊行物
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 77 (6), 1155-1159, 2013
公益社団法人 日本農芸化学会
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詳細情報 詳細情報について
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- CRID
- 1390282681456495616
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- NII論文ID
- 130003361120
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- NII書誌ID
- AA10824164
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- COI
- 1:STN:280:DC%2BC3sjhtFWgtA%3D%3D
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- ISSN
- 13476947
- 09168451
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- NDL書誌ID
- 024646740
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- PubMed
- 23748782
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- 本文言語コード
- en
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- データソース種別
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- NDL
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- PubMed
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