Production of Hydroxlated Flavonoids with Cytochrome P450 BM3 Variant F87V and Their Antioxidative Activities
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- KITAMURA Emi
- Department of Food and Nutrition, Japan Women's University
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- OTOMATSU Toshihiko
- KNC Bio Research Center, KNC Laboratories Co., Ltd.
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- MAEDA Chiemi
- Department of Food and Nutrition, Japan Women's University
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- AOKI Yoko
- Department of Food and Nutrition, Japan Women's University
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- OTA Chihiro
- Department of Food and Nutrition, Japan Women's University
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- MISAWA Norihiko
- Reseach Institute for Bioresources and Biotechnology, Ishikawa Prefectural University
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- SHINDO Kazutoshi
- Department of Food and Nutrition, Japan Women's University
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抄録
A variant of P450 BM3 with an F87V substitution [P450 BM3 (F87V)] is a substrate-promiscuous cytochrome P450 monooxygenase. We investigated the bioconversion of various flavonoids (favanones, chalcone, and isoflavone) by using recombinant Escherichia coli cells, which expressed the gene coding for P450 BM3 (F87V), to give their corresponding hydroxylated products. Potent antioxidative activities were observed in some of the products.
収録刊行物
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- Ｂｉｏｓｃｉｅｎｃｅ， Ｂｉｏｔｅｃｈｎｏｌｏｇｙ， ａｎｄ Ｂｉｏｃｈｅｍｉｓｔｒｙ
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Ｂｉｏｓｃｉｅｎｃｅ， Ｂｉｏｔｅｃｈｎｏｌｏｇｙ， ａｎｄ Ｂｉｏｃｈｅｍｉｓｔｒｙ 77 (6), 1340-1343, 2013
公益社団法人 日本農芸化学会
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詳細情報 詳細情報について
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- CRID
- 1390282681456496640
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- NII論文ID
- 10031184710
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- NII書誌ID
- AA10824164
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- COI
- 1:STN:280:DC%2BC3sjhtFWgtg%3D%3D
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- ISSN
- 13476947
- 09168451
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- NDL書誌ID
- 024647323
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- PubMed
- 23748780
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 使用不可