Peanut-Skin Polyphenols, Procyanidin A1 and Epicatechin-(4β→6)-epicatechin-(2β→O→7,4β→8)-catechin, Exert Cholesterol Micelle-Degrading Activity in Vitro

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  • TAMURA Tomoko
    Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture
  • INOUE Naoko
    Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture
  • OZAWA Megumi
    Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture
  • SHIMIZU-IBUKA Akiko
    Department of Material and Biological Chemistry, Faculty of Science, Yamagata University
  • ARAI Soichi
    Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture
  • ABE Naoki
    Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture
  • KOSHINO Hiroyuki
    RIKEN Advanced Science Institute
  • MURA Kiyoshi
    Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture

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  • Peanut-Skin Polyphenols, Procyanidin A1 and Epicatechin-(4 β→6)-epicatechin-(2 β→<i>O</i>→7, 4 β→8)-catechin, Exert Cholesterol Micelle-Degrading Activity <i>in Vitro</i>

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We identified epicatechin-(4 β→6)-epicatechin-(2 β→O→7, 4 β→8)-catechin (EEC) in the skin of the peanut (Arachis hypogaea L.). EEC (a trimer) showed more potent cholesterol micelle-degrading activity than procyanidin A1 (a dimer) did in vitro. The hypercholesterolemia suppressing effect of a peanut skin polyphenol on rats fed high-cholesterol diet in our preceding experiments might thus have been due primarily to a micelle degrading effect in the intestine.

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