Polymorphisms in the Human Apolipoprotein E Receptor 2 Gene in Japanese Sporadic Alzheimer's Disease Patients

  • HOSODA Akemi
    Graduate School of Human Life Science, Osaka City University
  • INOUE Takashi
    Laboratory for Developmental Neurobiology, Brain Science Institute
  • MAO Chang C.
    Center for Advanced Genome Research, Institute of Development, Aging, and Cancer, Tohoku University
  • JEONG Young-Hee
    Graduate School of Human Life Science, Osaka City University
  • YAMAGISHI Azumi
    Graduate School of Human Life Science, Osaka City University
  • YE Mingjuan
    Graduate School of Human Life Science, Osaka City University
  • YAMAMOTO Tokuo
    Center for Advanced Genome Research, Institute of Development, Aging, and Cancer, Tohoku University
  • KIM Dong-Ho
    Graduate School of Human Life Science, Osaka City University
  • SAEKI Shigeru
    Graduate School of Human Life Science, Osaka City University

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Abstract

Apolipoprotein E (apoE) polymorphism is associated with onset of Alzheimer’s disease (AD). We found seven polymorphisms in apoE receptor 2 (ApoER2), an apoE-binding receptor, in Japanese sporadic AD patients, but no association of ApoER2 polymorphisms with AD. We consider that the functions of ApoER2 in the brain may be compensated for by those of other apoE-binding receptors such as VLDL receptor.

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