Enzymes That Control the Conversion of L-Tryptophan-nicotinamide and the Urinary Excretion Ratio (N¹-Methyl-2-pyridone-5-carboxamide + N¹-Methyl-4-pyridone-3-carboxamide)/N¹-Methylnicotinamide in Mice

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  • SHIBATA Katsumi
    Department of Nutrition, School of Human Cultures, The University of Shiga Prefecture
  • MORITA Nobuya
    Department of Nutrition, School of Human Cultures, The University of Shiga Prefecture
  • SHIBATA Yoshika
    Department of Nutrition, School of Human Cultures, The University of Shiga Prefecture
  • FUKUWATARI Tsutomu
    Department of Nutrition, School of Human Cultures, The University of Shiga Prefecture

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タイトル別名
  • Enzymes That Control the Conversion of <small>L</small>-Tryptophan-nicotinamide and the Urinary Excretion Ratio (<i>N</i><sup>1</sup>-Methyl-2-pyridone-5-carboxamide + <i>N</i><sup>1</sup>-Methyl-4-pyridone-3-carboxamide)/<i>N</i><sup>1</sup>-Methylnicotinamide in Mice
  • Enzymes That Control the Conversion of<scp>L</scp>-Tryptophan-nicotinamide and the Urinary Excretion Ratio (<i>N</i><sup>1</sup>-Methyl-2-pyridone-5-carboxamide +<i>N</i><sup>1</sup>-Methyl-4-pyridone-3-carboxamide)/<i>N</i><sup>1</sup>-Methylnicotinamide in Mice

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説明

There is little information on L-tryptophan→nicotinamide metabolism in mice. In the present study, we investigated the two important nutritional factors involved in metabolism L-tryptophan→nicotinamide; one is the amount of nicotinamide synthesized from L-tryptophan, and the other is the urine ratio (N1-methyl-2-pyridone-5-carboxamide + N1-methyl-4-pyridone-3-carboxamide)/N1-methylnicotinamide. The order of the percentages of nicotinamide synthesized from L-tryptophan was as follows: CBA strain mice (conversion percentage 0.41%) < BALB strain mice (0.82%) < C57BL/6 strain mice (1.13%) < ICR strain mice (1.70%). Urinary excretion of quinolinic acid was correlated with urinary excretion of the sum of nicotinamide and its catabolites (p<0.0001). The urine sum, which reflects the conversion of L-tryptophan→nicotinamide, correlated well with the activity of 3-hydroxyanthranilic acid dioxygenase (p=0.040). A nutritional indicator, the urine ratio (N1-methyl-2-pyridone-5-carboxamide + N1-methyl-4-pyridone-3-carboxamide)/N1-methylnicotinamide, was controlled by the activity of N1-methyl-2-pyridone-5-carboxamide-forming N1-methylnicotinamide oxidase.

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