Biosynthetic Mechanism for <small>L</small>-Gulose in Main Polar Lipids of <i>Thermoplasma acidophilum</i> and Possible Resemblance to Plant Ascorbic Acid Biosynthesis

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  • YAMAUCHI Noriaki
    Department of Earth and Planetary Sciences, Graduate School of Sciences, Kyushu University
  • NAKAYAMA Yusuke
    Department of Earth and Planetary Sciences, Graduate School of Sciences, Kyushu University

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  • Biosynthetic Mechanism for L-Gulose in Main Polar Lipids of Thermoplasma acidophilum and Possible Resemblance to Plant Ascorbic Acid Biosynthesis
  • Biosynthetic Mechanism for<scp>L</scp>-Gulose in Main Polar Lipids of<i>Thermoplasma acidophilum</i>and Possible Resemblance to Plant Ascorbic Acid Biosynthesis

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L-Gulose is a very rare sugar, but appears as a sugar component of the main polar lipids characteristic in such a thermophilic archaeon as Thermoplasma acidophilum that lives without cell walls in a highly acidic environment. The biosynthesis of L-gulose in this thermophilic organism was investigated with deuterium-labeling experiments. L-Gulose was found to be biosynthesized from D-glucose via stepwise stereochemical inversion at C-2 and C-5. The involvement of an epimerase related to GDP-mannose 3,5-epimerase, the key enzyme of plant ascorbate biosynthesis, was also suggested in this C-5 inversion. The resemblance of L-gulose biosynthesis in archaea and plants might be suggested from these results.

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