Fermented Barley Extract Suppresses the Development of Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice, Probably by Inhibiting Inflammatory Cytokines

DOI Web Site Web Site 被引用文献5件 参考文献35件

この論文をさがす

説明

We have found that fermented barley extract (FBE), prepared from barley shochu residue, alleviates allergic rhinitis in OVA-sensitized mice. In this study, we examined to determine whether FBE suppresses the development of atopic dermatitis (AD)-like skin lesions in NC/Nga mice. The development of AD-like skin lesions in a 5% FBE containing diet group was significantly inhibited, and scratching behavior, one of aggravating factors, was also suppressed. Neither serum immunoglobulin E (IgE) levels nor interleukin (IL)-4 production by spleen cells in the 5% FBE diet group was found to be significantly reduced. On the other hand, interferon-gamma (IFN-γ) and IL-17 production by spleen cells in the 5% FBE diet group was significantly reduced. Hence it was assumed that FBE alleviates AD-like skin lesions in NC/Nga mice, probably by modulating the cytokine production involved in chronic inflammation, such as IFN-γ or IL-17.

収録刊行物

被引用文献 (5)*注記

もっと見る

参考文献 (35)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ