Award review: Biogenesis of outer membranes in gram-negative bacteria
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- TOKUDA Hajime
- Institute of Molecular and Cellular Biosciences, University of Tokyo
書誌事項
- タイトル別名
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- Biogenesis of Outer Membranes in Gram-Negative Bacteria
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説明
The outer membrane, an essential organelle of Gram-negative bacteria, is composed of four major components: lipopolysaccharide, phospholipids, β-barrel proteins, and lipoproteins. The mechanisms underlying the transport of these components to outer membranes are currently under extensive examination. Among them, the sorting of lipoproteins to the outer membrane of Escherichia coli has been clarified in detail. The Lol system, composed of five proteins, catalyzes outer membrane sorting of lipoproteins. Various Lpt proteins have recently been identified as factors involved in the transport of lipopolysaccharide to the outer membrane, although the mechanism remains largely unknown. Proteins with α-helical membrane spanning segments are found in the inner membrane, whereas amphipathic β-barrel proteins span the outer membrane. These β-barrel proteins are inserted into the outer membranes through a central core protein BamA (YaeT) with the help of four outer membrane lipoproteins. In contrast, little is known about how phospholipids are transported to the outer membrane.
収録刊行物
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 73 (3), 465-473, 2009
公益社団法人 日本農芸化学会
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詳細情報 詳細情報について
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- CRID
- 1390282681456891520
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- NII論文ID
- 10027537908
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- NII書誌ID
- AA10824164
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- ISSN
- 13476947
- 09168451
- http://id.crossref.org/issn/13476947
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- NDL書誌ID
- 10198832
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可