β-Carotene Modulates the Immunological Function of RAW264, a Murine Macrophage Cell Line, by Enhancing the Level of Intracellular Glutathione

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  • IMAMURA Tomomi
    Department of Food Science, Graduate School of Nutrition and Biosciences, The University of Tokushima
  • BANDO Noriko
    Department of Food Science, Graduate School of Nutrition and Biosciences, The University of Tokushima
  • YAMANISHI Rintaro
    Department of Food Science, Graduate School of Nutrition and Biosciences, The University of Tokushima

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  • ベータ Carotene Modulates the Immunological Function of RAW264 a Murine Macrophage Cell Line by Enhancing the Level of Intracellular Glutathione

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Abstract

The activities of β-carotene on redox status and the immune functions of RAW264 cells, a murine macrophage cell line, were investigated. Supplementation with β-carotene for RAW264 cells resulted in apparently inconsistent redox indices: lipid peroxidation was enhanced but intracellular oxidation was moderately attenuated. Attenuated intracellular oxidation was endorsed by an increase in glutathione accompanied by up-regulated transcription of a subunit of γ-glutamylcysteine synthetase, the rate-limiting enzyme for glutathione synthesis. α-Tocopherol, which can quench lipid peroxidation by free radical, neither inhibited that by β-carotene nor influenced the intracellular redox status. Lipopolysaccharide-stimulated transcriptions of IL-1β and IL-12 p40 in RAW264 were inhibited by β-carotene but not by α-tocopherol. These results indicate that β-carotene, which can modulate the intracellular redox status of macrophages by enhancing the level of intracellular glutathione, is related to the immune functions of macrophages.

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