Huang-Lian-Jie-Du-Tang Supplemented with<i>Schisandra chinensis</i>Baill. and<i>Polygonatum odoratum</i>Druce Improved Glucose Tolerance by Potentiating Insulinotropic Actions in Islets in 90% Pancreatectomized Diabetic Rats
-
- PARK Sunmin
- Deptartment of Food and Nutrition, College of Natural Science, Hoseo University
-
- HONG Sang Mee
- Deptartment of Food and Nutrition, College of Natural Science, Hoseo University
-
- AHN Il Sung
- Deptartment of Food and Nutrition, College of Natural Science, Hoseo University
-
- KIM Yang Jin
- Naturalbiopharms Co., Ltd.
-
- LEE Jung Bok
- Naturalbiopharms Co., Ltd.
書誌事項
- タイトル別名
-
- Huang-Lian-Jie-Du-Tang Supplemented with Schisandra chinensis Baill. and Polygonatum odoratum Druce Improved Glucose Tolerance by Potentiating Insulinotropic Actions in Islets in 90% Pancreatectomized Diabetic Rats
この論文をさがす
抄録
We investigated to determine what effects, if any, the respective water extracts of Radix scutellariae (RS), Fructus schisandrae chinensis (FSC), Huang-Lian-Jie-Du-Tang (HLJDT), and HLJDT supplemented with FSC, and Rhizoma Polygonati odorati (HLJDT-M) would have on glucose tolerance by modulating glucose-stimulated insulin secretion, β-cell mass, and morphometry in 90% pancreatectomized (Px) diabetic rats fed high-fat diets. Through the elevation of intracellular cAMP levels, FSC RS, HLJDT, and HLJDT-M increased insulin secretion in Min6 cells and GLP-1 secretion in NCI-H716 cells. After an 8-week period of treatment, it was found that HLJDT-M improved glucose tolerance in an oral glucose tolerance test in Px rats. HLJDT-M also potentiated first- and second-phase insulin secretion, but RS and HLJDT elevated only the second phase at hyperglycemic clamp. RS and HLJDT increased β-cell mass by hyperplasia and hypertrophy, while HLJDT-M increased it only by hyperplasia. The rise in hyperplasia was associated with elevated IRS2 and PDX-1 expression in the islets. In conclusion, HLJDT-M worked as an anti-diabetic prescription by enhancing insulinotropic actions in diabetic rats.
収録刊行物
-
- Bioscience, Biotechnology, and Biochemistry
-
Bioscience, Biotechnology, and Biochemistry 73 (11), 2384-2392, 2009
公益社団法人 日本農芸化学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390282681457351168
-
- NII論文ID
- 10027547458
-
- NII書誌ID
- AA10824164
-
- ISSN
- 13476947
- 09168451
-
- NDL書誌ID
- 10458806
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可