Bone Loss and Degradation of Bone Quality in the Human Femur after Total Hip Arthroplasty under Stress-Shielding by Titanium-Based Implant

  • Noyama Yoshihiro
    Division of Materials and Manufacturing Science, Graduate School of Engineering, Osaka University Department of Research and Development Division, Nakashima Medical Co., Ltd.
  • Miura Takuya
    Division of Materials and Manufacturing Science, Graduate School of Engineering, Osaka University
  • Ishimoto Takuya
    Division of Materials and Manufacturing Science, Graduate School of Engineering, Osaka University
  • Ikeo Naoko
    Division of Materials and Manufacturing Science, Graduate School of Engineering, Osaka University
  • Niinomi Mitsuo
    Department of Bio-Materials Science, Materials Development Division, Institute for Materials Research, Tohoku University
  • Nakano Takayoshi
    Division of Materials and Manufacturing Science, Graduate School of Engineering, Osaka University

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Other Title
  • 人工股関節置換後にチタン基インプラントより生じた応力遮蔽にともなうヒト大腿骨の骨損失および骨質劣化
  • ジンコウ コ カンセツ チカン ゴ ニ チタンキ インプラント ヨリ ショウジタ オウリョク シャヘイ ニ トモナウ ヒト ダイタイコツ ノ ホネ ソンシツ オヨビ コッシツ レッカ

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Abstract

  The present work was aimed at understanding the stress-shielding caused by hip-joint implantation into a femur by using a human cadaver with a cementless hip implant. In particular, bone quality was assessed from the standpoint of preferential c-axis orientation of biological apatite (BAp). Comparing the implanted side to the non-implanted side, a finite element analysis (FEA) indicated that artificial hip-joint implantation had a significant stress-shielding on the femur. The results also showed a remarkable decrease in the degree of preferential BAp orientation as well as bone loss in Haversial canal in the medial-proximal femur. This is the first report showing a reduction in the degree of preferential BAp orientation due to a stress-shielding after artificial hip-joint implantation. Since preferential BAp orientation is an important parameter for determining bone mechanical function, these findings should be taken into account in future artificial hip-joint designs, especially those involving the stem component.<br>

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