Combinatorial Chemistry.

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  • コンビナトリアルケミストリー

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Combinatorial chemistry is a novel and innovative technology to generate and screen a large number of compounds simultaneously. Traditionally, new drag lead compounds were discovered by screening sources of natural products or collections of compounds from chemical synthesis in pharmaceutical companies. Recently, computer assisted structure-activity based approaches enable the “rational drug design” to avoid laborious and serendipitous synthesis. More recently, combinatorial chemistry–sometimes referred to as “irrational drug design”-has emerged and is believed to give a big advantage over traditional methods.

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