裁判化学におけるＣａｐｉｌｌａｒｙ　ＧＣ／ＭＳの薬物同定への応用Ｉ　ヘロインを摂取したヒト尿からの６‐アセチルモルヒネの直接検出

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タイトル別名
  • Application of Capillary GC/MS for Identification of Drugs on Forensic Chemistry I: Direct Detection of 6-Acetylmorphine in Urine Samples of Heroin Abusers.
  • 裁判化学におけるCapillary GC/MSの薬物同定への応用-1-ヘロインを摂取したヒト尿からの6-アセチルモルヒネの直接検出
  • サイバン カガク ニ オケル Capillary GC MS ノ ヤクブツ ド

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It has been considered that heroin and its metabolites in human urine play a main evidence in most cases of heroin use. However heroin is quickly metabolized and run out from a body. There are a few reports and data on their detective research from human urine samples, but very few about underivatized methods. This study was aimed at examining whether heroin metabolites like as 6-acetylmorphine and morphine could be detected from urine samples by GC/MS without derivatization. Heroin and its metabolites in the human urine sample was directly extracted with chloroform-isopropanol (3:1, pH↔9.5, 20°C) and the extracts were analyzed by GC/MS. In the results, we found some heroin metabolites like 6-acetylmorphine and morphine in the urine sample of a drug addict.<br>The above data suggest that our direct method is useful for evaluating whether a person use heroin or not. It may also be possible to detect metabolites of heroin from urine samples of heroin abusers, if urine samples were quickly taken from the bodys (at least 4 or 5 hours after use of heroin).

収録刊行物

  • 質量分析

    質量分析 40 (4), 231-234, 1992

    一般社団法人 日本質量分析学会

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