Biological Mass Spectrometry. Examination by GC/MS of Mechanism for Production of Phospholipid Mediators.

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  • TOKUMURA Akira
    Faculty of Pharmaceutical Sciences, The University of Tokushima

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  • ＧＣ／ＭＳによるリン脂質メディエー夕ー産生機構の解析
  • GC/MSによるリン脂質メディエーター産生機構の解析
  • GC MS ニ ヨル リン シシツ メディエーター サンセイ キコウ ノ カイセキ

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Structures of phosphatidylcholines having an oxidatively shortened fatty acyl group resemble that of the platelet-activating factor (PAF), a chemical mediator of inflammation, and therefore they are classified as PAF-like lipids. Gas chromatography-mass spectrometry has been utilized for analysis of the class, subclass and molecular species compositions of PAF-like lipids, providing usefel informations on mechanisms of their formation. Gas chromatography-mass spectrometry was also found to be useful for the determination of lysophosphatidic acid, a growth factor in animal plasma, and clarification of mechanisms of its formation.

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