Development of High-Resolution Scanning Electrochemical Microscopy for Nanoscale Topography and Electrochemical Simultaneous Imaging

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  • TAKAHASHI Yasufumi
    Division of Electrical Engineering and Computer Science, Kanazawa University PRESTO, JST

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  • Comprehensive Paper : Young Researcher Award of The Electrochemical Society of Japan (Sano Award) : Development of High-Resolution Scanning Electrochemical Microscopy for Nanoscale Topography and Electrochemical Simultaneous Imaging

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Abstract

This article reviews our recent progress in the development of high-resolution scanning electrochemical microscopy (SECM) and its application to biological samples. SECM uses an ultramicroelectrode (UME) as a probe and a scanning mechanical stage for controlling the probe position. To improve the resolution of SECM, we have developed a fabrication method for pyrolytic carbon nanoelectrodes and a current feedback system for probe–sample distance control. The current feedback system effectively provides high-quality electrochemical and non-contact topography images because the current signal depends on the probe–sample distance. High-resolution SECM has overcome the limit of microscale imaging resolution and enabled the imaging of local regions within cells. In this study, we address four topics: nanoelectrode fabrication, current feedback probe–sample distance control systems, membrane protein imaging, and neurotransmitter detection.

Journal

  • Electrochemistry

    Electrochemistry 84 (9), 662-666, 2016

    The Electrochemical Society of Japan

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