In vivo antithrombogenicity of poly(tetrafluoroethylene) radiation-graft copolymerized with acrylamide.

DOI Web Site

Bibliographic Information

Other Title
  • アクリルアミドを放射線グラフト共重合したポリテトラフルオロエチレンの生体内抗血栓性
  • アクリルアミド オ ホウシャセン グラフト キョウジュウゴウシタ ポリテトラフ

Search this article

Description

In order to prepare an antithrombogenic material by making polymer surfaces hydrophilic, acrylamide (AAm) was radiation-graft copolymerized onto poly (tetrafluoroethylene) (PTFE) tubes by preirradiation in Arand the following treatment with a monomer aqueous solution. The grafting percentage determined from the weight increment was so small (below 0.3%) that the surface grafting percentage was calculated by ESCA for the grafted tubes. The in vivo antithrombogenicity was evaluated by relative patent time in the implantation into canine peripheral veins and its relation to the contact angle of water or surface grafting percentage was discussed. From the results of ESCA measured at the photoelctron takeoff angles of 15° and 90°, the graft copolymerization was suggested to proceed into a deep layer from a surface thin layer (below 2 nm) with low grafting. A grafting of 150% from 15°-measurement (the sampling depth of ca. 2nm) or 500% from 90°-measurement (the sampling depth of ca. 8 nm) was found to result in an antithrombogenic surface superior to the original one and also the grafted surface with the lowest contact angle of 26°.

Journal

  • KOBUNSHI RONBUNSHU

    KOBUNSHI RONBUNSHU 44 (6), 429-436, 1987

    The Society of Polymer Science, Japan

Keywords

Details 詳細情報について

Report a problem

Back to top