Surface and Interface-New Functions of Biorelated Polymers I. Thermo-Responsive Microcapsules Using Poly(N-isopropylacrylamide).

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  • KIDCHOB Tongjit
    Department of Material Chemistry, Graduate School of Engineering, Kyoto University
  • KIMURA Shunsaku
    Department of Material Chemistry, Graduate School of Engineering, Kyoto University
  • IMANISHI Yukio
    Graduate School of Material Science, Nara Institute of Science and Technology

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Other Title
  • 高分子の表面・界面　生体関連分野における機能発現Ｉ　　ポリ（Ｎ‐イソプロピルアクリルアミド）を組み込んだマイクロカプセルからの温度応答性放出制御
  • ポリ N イソプロピルアクリルアミド オ クミコンダ マイクロカプセル カラ

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Abstract

Two different types of thermo-responsive microcapsules were prepared by combining biodegradable polymer microcapsules and poly (N-isopropylacrylamide) (PNIPAAm). First, PNIPAAm was grafted on the surface of the polypeptide microcapsule by a new method of surface grafting. Dextran release from the microcapsule was faster below the lower critical solution temperature (LCST) of PNIPAAm than the rate above it. Then the temperature changed across the LCST, a reversible and thermo-responsive release from the microcapsule was observed. Notably, the transition of the release rate by changing the temperature occurred quickly in a narrow temperature range. Secondly, poly (L-lactic acid) (PLLA) microcapsules containing PNIPAAm gel were prepared. Internal cavities of PLLA microcapsules were filled partly or completely with PNIPAAm gel to obtain microcapsules for thermo-responsive drug release. The dextran release from the microcapsules showed a positively thermo-responsive release as the release was accelerated at the temperatures above the LCST, and nearly stopped below the LCST. The release rate of dextran was dependent on the amount of PNIPAAm gel loaded in the microcapsules as well as on the size of the internal cavities. The response rate of the microcapsules was also fast.

Journal

  • KOBUNSHI RONBUNSHU

    KOBUNSHI RONBUNSHU 55 (4), 192-199, 1998

    The Society of Polymer Science, Japan

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