ポリ‐Ｌ‐リジン‐ポリアクリル酸コンプレックスの構造

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タイトル別名
  • Structure of Poly-<SUB>L</SUB>-lysine-Poly (acrylic acid) Complex
  • ポリーL リジン ポリアクリルサン コンプレックス ノ コウゾウ

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Kabanov, et al., reported that a complex could be formed between poly-L-lysine (I) and poly (acrylic acid) (II), so as to stabilize the α-helix of I. In order to confirm this important result, the complex formation between I and various dicarboxylic acids of different molecular lengths has been examined. Glutaric acid, whose extended chain length coincides with the distance between the adjacent amino groups of the I chain in the form of the α-helix, was found to stabilize the α-helix. The structures of the complexes of I with oligo-and poly (acrylic acid) s were also studied by ORD in the aqueous solutions and by X-ray analysis in the crystalline states. The results showed that the β-structure is prefered to the α helical conformation. This might be attributable to the fact that the distance between the neighboring carboxylic groups along II is shorter than that between the adjacent amino groups of I in the form of α-helix, while it coincides with the distance in the form of β-structure.

収録刊行物

  • 高分子論文集

    高分子論文集 32 (10), 618-626, 1975

    公益社団法人 高分子学会

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