Investigation of Bio-Nano Interfaces for Activating Cell Functions

DOI Web Site 2 Citations 178 References
  • TAGAYA Motohiro
    Department of Materials Science and Technology, Nagaoka University of Technology

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  • 細胞機能を活性化するバイオナノ接合界面の解明
  • サイボウ キノウ オ カッセイカ スル バイオナノ セツゴウ カイメン ノ カイメイ

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Abstract

When biomaterials are implanted into a body, proteins in the body fluid are adsorbed and the body cells adhere to the surfaces. Cells respond differently with different biomaterials. Hence, proper understanding of cellular response to biomaterial surfaces is crucial for successful tissue regeneration and integration. Quartz crystal microbalance with dissipation (QCM-D) is one of the most advanced in situ analyzing techniques to detect interfacial interactions of the protein adlayers between biomaterial surfaces and cells. This review article precisely describes how to analyze interfacial phenomena of the protein adsorption and subsequent cell adhesion using the QCM-D technique. In particular, we focus on understanding the biocompatibility of interfaces by explaining the role of biomaterial surfaces in protein-mediation. The viscoelastic properties of the interfaces are estimated by a Voigt-based viscoelastic model obtained from the frequency shift (Δf) and dissipation shift (ΔD) curves. Different protein adsorption and cell adhesion processes have been analyzed on different biomaterial surfaces. This approach clarifies several ambiguities of the interfacial phenomena between biomaterials and cells, and helps to design new biomaterials to be implanted in the human body.

Journal

  • KOBUNSHI RONBUNSHU

    KOBUNSHI RONBUNSHU 70 (8), 398-418, 2013

    The Society of Polymer Science, Japan

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