Microbial Synthesis of Polyhydroxyalkanoate Copolymer Containing 3-Hydroxy-4-methylvalerate Unit: Recent Development and Perspective

  • SAIKA Azusa
    Department of Innovative and Engineered Materials, Tokyo Institute of Technology
  • TSUGE Takeharu
    Department of Innovative and Engineered Materials, Tokyo Institute of Technology

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Other Title
  • 分岐脂肪酸ユニット3H4MVを含む微生物ポリエステル<br/>―合成法の開発と展望―
  • 分岐脂肪酸ユニット3H4MVを含む微生物ポリエステル : 合成法の開発と展望
  • ブンキ シボウサン ユニット 3H4MV オ フクム ビセイブツ ポリエステル : ゴウセイホウ ノ カイハツ ト テンボウ

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Abstract

Polyhydroxyalkanoates (PHAs) are bio-based and biodegradable polyester synthesized by a wide variety of bacteria. To enhance the usability of PHA, we need to improve the material performance for wide-ranging applications and reduce the production cost during fermentation. We have developed biosynthesis methods for a novel PHA copolymer consisting of 3-hydroxybutyrate (3HB) and 3-hydroxy-4-methylvalerate (3H4MV) [P(3HB-co-3H4MV)], which shows improved long-term stability and processability than other known PHA copolymers. P(3HB-co-3H4MV) has the potential to broaden the use of PHA if it can be produced from inexpensive sugars with controlled 3H4MV fraction. This article summarizes recent advances in the study of P(3HB-co-3H4MV) biosynthesis.

Journal

  • KOBUNSHI RONBUNSHU

    KOBUNSHI RONBUNSHU 70 (10), 513-519, 2013

    The Society of Polymer Science, Japan

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