Cell-Selective Peptide Distribution in Human Collagen Proteins

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  • KANIE Kei
    Department of Biotechnology, Graduate School of Engineering, Nagoya University
  • NARITA Yuji
    Department of Cardiac Surgery, Nagoya University Graduate School of Medicine
  • KUWABARA Fumiaki
    Department of Cardiac Surgery, Nagoya University Graduate School of Medicine
  • SATAKE Makoto
    Integrative Technology Research Institute, TEIJIN LIMITED
  • HONDA Susumu
    Integrative Technology Research Institute, TEIJIN LIMITED
  • KANEKO Hiroaki
    Integrative Technology Research Institute, TEIJIN LIMITED
  • HONDA Hiroyuki
    Department of Biotechnology, Graduate School of Engineering, Nagoya University
  • KATO Ryuji
    Department of Biotechnology, Graduate School of Engineering, Nagoya University

Bibliographic Information

Other Title
  • ヒト Collagen における細胞選択的ペプチドの分布
  • ヒト Collagen ニ オケル サイボウ センタクテキ ペプチド ノ ブンプ

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Abstract

To reduce risks in vascular implants, the design of effective coating polymer for balancing the organization and growth of surrounding cells is important. To design such polymer by learning the mechanism of native extracellular matrix (ECM), we had investigated ECM-specific peptides with cell-selectivity to control the adhesion balance of endothelial cells (ECs) and smooth muscle cells (SMCs). From our high-throughput comparative screening using in silico analysis and peptide array screening platform, we had found that there are various types of EC-selective and SMC-selective peptides in human collagen type IV. In this report, we mapped the distribution of obtained EC-and SMC-selective peptides in the collagen, and extracted a new design policy of cell-selective polymers for medical implant surface modification.<br>

Journal

  • KOBUNSHI RONBUNSHU

    KOBUNSHI RONBUNSHU 69 (3), 129-134, 2012

    The Society of Polymer Science, Japan

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