Synthesis and Characterization of Polyglycolic Acid via Sequential Melt-Solid Ring-Opening Polymerization of Glycolide

SATO Hiroyuki, KOBAYASHI Fuminori, ICHIKAWA Yukio, OISHI Yoshiyuki

doi:10.1295/koron.69.60

Bibliographic Information

Other Title

グリコリドの連続的溶融-固相開環重合法によるポリグリコール酸の合成と性質

Description

The sequential melt-solid ring-opening polymerization of glycolide was innovated and identified in order to produce high molecular weight poly(glycolic acid) (PGA), which was expected to be applicable for industrial mass production. This method as a typical procedure was carried out by using SnCl₂·2H₂O and 1-dodecanol as catalyst and initiator respectively at 170°C. The obtained polymer was characterized as a well-defined PGA structure by NMR and DSC, it was evaluated by SEC as having the weight average molecular weight (M_w) of 280,000 and the distribution (M_w/M_n) of 2.0. The polymer especially from the M_w was clarified to be at least comparable to the polymers reported in the previous literature or to the commercially available suture material. The polymerization rate constants (k_ap) were measured, and the activation energy of k_ap was calculated to be 110±3 kJ/mol at temperatures between 140°C and 170°C. The polymerization rate depended on the concentration of catalyst. The alcohol as initiator enhanced the polymerization rate as compared with H₂O. The initiator provided the chemical structure of -COOH or -COOR at the polymer end group and its concentrations determined the molecular weight (M_w) of PGA. The polymerization temperature also influenced the M_w control of PGA.<br>

Journal

KOBUNSHI RONBUNSHU

KOBUNSHI RONBUNSHU 69 (2), 60-70, 2012

The Society of Polymer Science, Japan

Keywords

Details 詳細情報について

CRID: 1390282681503363200

NII Article ID: 130004489381

DOI: 10.1295/koron.69.60

COI: 1:CAS:528:DC%2BC38Xjt1CktLc%3D

ISSN: 18815685; 03862186

Text Lang: ja

Data Source

JaLC
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CiNii Articles

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