Secondary leukemia developing after treatment for cancer of the maxilla.

DOI 8 References Open Access
  • KURACHI Yoichi
    Second Department of Oral and Maxillofacial Surgery, Showa University School of Dentistry
  • YAMAGUCHI Singo
    Second Department of Oral and Maxillofacial Surgery, Showa University School of Dentistry
  • HATORI Hitoshi
    Second Department of Oral and Maxillofacial Surgery, Showa University School of Dentistry
  • KAMIZYO Ryutaro
    Second Department of Oral and Maxillofacial Surgery, Showa University School of Dentistry
  • IWASE Masayasu
    Second Department of Oral and Maxillofacial Surgery, Showa University School of Dentistry
  • NAGUMO Masao
    Second Department of Oral and Maxillofacial Surgery, Showa University School of Dentistry

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  • 上顎癌治療後に二次性白血病の発症が疑われた１例

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The development of leukemia after successful treatment of a malignancy is one of the most feared complications.<BR>We describe a patient with secondary leukemia that developed after chemotherapy and radiotherapy for cancer of the maxilla.<BR>A 54-year-old man presented in July 1989 with a gingival swelling in the right side of the maxilla. Squamous cell carcinoma was diagnosed on examination of a biopsy specimen. He was treated with a combination of surgery, radiotherapy, and chemotherapy. After complete remission for 3 years, pancytopenia was detected in August 1993, and acute leukemia was diagnosed on examination of a specimen obtained by bone marrow aspiration. Chromosomal analysis showed partial deletion of 5 q-. Chemotherapy failed to induce remission, and the patient died 39 days later.

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