Anti-cancer drug sensitivity testing in transplantable human osteosarcoma from mandible in nude mouse.

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  • NOMURA Jouji
    Department of Oral Surgery, School of Medicine, Mie University
  • TAGAWA Toshirou
    Department of Oral Surgery, School of Medicine, Mie University
  • MATSUMOTO Jun
    Department of Oral Surgery, School of Medicine, Mie University
  • INUI Madoka
    Department of Oral Surgery, School of Medicine, Mie University
  • KIHIRA Hiroyuki
    Department of Oral Surgery, School of Medicine, Mie University

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  • ヌードマウス可移植性ヒト下顎骨由来骨肉腫累代株における制癌剤感受性試験

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Abstract

An anti-cancer drug sensitivity test was performed using a transplantable human osteosarcoma originated in the mandible (HOSIVIN-1). The drugs tested in this study were Adriamycin (ADM), Cis-platinum (CDDP), and Methotrexate (MTX)(high and low-dose). The effect of the drugs were judged according to the Battelle Columbus Laboratories Protocol (BCLP), and the following results were obtained.<BR>1) Growth inhibition was seen with all drugs.<BR>2) With respect to the duration of effect and the maximum rate of tumor inhibition, the most effective drug was losv-dose MTX followed by CDDP, high-dose MTX and ADM in that order.<BR>3) In the substantial weight change, only low-dose MTX group showed no weight loss. Refering to its low incidence of side effect as well, it was suggested that low-dose MIX was most useful in this experiment.

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