播種性血管内凝固症候群（ＤＩＣ）に関する実験的研究　１　　エンドトキシンを用いた実験的家兎ＤＩＣモデルの作製とその診断基準試案（ＤＩＣスコア）

DOI オープンアクセス

書誌事項

タイトル別名
  • Experimental study on disseminated intravascular coagulation(DIC). 1. Experimental model of DIC induced by endotoxin in rabbits and diagnostic criteria for DIC(DIC score).
  • 1. Experimental model of DIC induced by endotoxin in rabbits and diagnostic criteria for DIC (DIC score)
  • 1. エンドトキシンを用いた実験的家兎DICモデルの作製とその診断基準試案 (DICスコア)

この論文をさがす

説明

The purpose of the present study is to clarify the disease of disseminated intravascular coagulation (DIC).<BR>We designed an experimental model of DIC in rabbits induced by continuous infusion of endotoxin (ET) for three hours. The animals were divide into four groups as follows;<BR>Group I: infusion with ET (0.1mg/kg)+physiological saline<BR>Group II: infusion with ET (1.0mg/kg)+physiological saline<BR>Group III: infusion with ET (3.0mg/kg)+physiological saline<BR>Group IV: infusion with physiological saline only (control).<BR>Tentative diagnostic criteria for experimental DIC were proposed as DIC score including various blood parameters and pathological findings (micro-clot formation in lung and kidney). The results indicated that aggravations of blood parameters and pathological findings were dependent upon the dose of ET, and Group III made the highest score in on studies.<BR>From these results, we may conclude that Group III was considered to be useful as DIC model in rabbits.

収録刊行物

キーワード

詳細情報 詳細情報について

  • CRID
    1390282681507105664
  • NII論文ID
    130001357393
  • DOI
    10.5794/jjoms.33.1308
  • ISSN
    21861579
    00215163
  • 本文言語コード
    ja
  • データソース種別
    • JaLC
    • Crossref
    • CiNii Articles
    • OpenAIRE
  • 抄録ライセンスフラグ
    使用不可

問題の指摘

ページトップへ