Long-term potentiation of synaptic transmission by synthetic mast cell degranulating(MCD) peptide.
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- IKENAKA Kazuhiro
- Institute for Protein Research, Osaka University
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- KONDO Tetsuro
- Institute for Protein Research, Osaka University
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- FUJIMOTO Ichiro
- Institute for Protein Research, Osaka University
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- AIMOTO Saburo
- Institute for Protein Research, Osaka University
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- HOJO Hironobu
- Institute for Protein Research, Osaka University
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- MIKOSHIBA Katsuhiko
- Institute for Protein Research, Osaka University
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- KATO Hiroshi
- Department of Physiology, Yamagata University School of Medicine
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- ITO Ken-ichi
- Department of Physiology, Yamagata University School of Medicine
Bibliographic Information
- Other Title
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- ハチ毒MCDペプチドによるシナプス伝達効率長期増強作用
- ハチ ドク MCD ペプチド ニ ヨル シナプス デンタツ コウリツ チョウキ
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Abstract
A bee venom, mast cell degranulating peptide (MCD), was synthesized by stepwise formation of the two distinct disulfide bridges. This synthetic peptides with mast cell degrahulating activity MCD induced long-term potentiation (LTP) in the CAl region of hippocampus, while other peptides with mast cell degranulating activity apamin and mastoparan did not. This and other results using derivatives of the synthetic MCD suggest that a rigid structure is required for the LTP induction by MCD. Two antagonists of the N-methyl-D-aspartate (NMDA) receptor, AP5 and MK801, did not block the MCD induced-LTP. Moreover, the efficacy of the synaptic transmission in the slice which had been maximally activated by tetanic stimulation was further potentiated by MCD treatment. These results indicate that two quite distinct pathways for LTP formation exist in the CAl region of the hippocampus.
Journal
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- Seibutsu Butsuri
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Seibutsu Butsuri 30 (1), 22-27, 1990
The Biophysical Society of Japan General Incorporated Association
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Details 詳細情報について
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- CRID
- 1390282681507416064
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- NII Article ID
- 130000722652
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- NII Book ID
- AN00129693
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- ISSN
- 13474219
- 05824052
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- NDL BIB ID
- 3656243
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed