Relation of telomerase reverse transcriptase (TERT) expression to transcriptional factor Sp1 during carcinogenesis in the hamster tongue
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- MIURA Masayoshi
- Department of Oral and Maxillofacial Surgery, Fukuoka Dental College
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- HIDAKA Keitaro
- Department of General Dentistry, Fukuoka Dental College
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- IWAHASHI Teruaki
- Department of Morphological Biology, Fukuoka Dental College
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- UCHIDA Ryuji
- Department of Oral and Maxillofacial Surgery, Fukuoka Dental College
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- OKAMURA Kazuhiko
- Department of Morphological Biology, Fukuoka Dental College
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- OZEKI Satoru
- Department of Oral and Maxillofacial Surgery, Fukuoka Dental College
Bibliographic Information
- Other Title
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- ハムスター舌の発癌過程におけるtelomerase reverse transcriptase(TERT)の発現と転写因子Sp1の関連性
- ハムスター ジタ ノ ハツガン カテイ ニ オケル telomerase reverse transcriptase TERT ノ ハツゲン ト テンシャ インシ Sp1 ノ カンレンセイ
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Abstract
Telomerase reverse transcriptase (TERT) is acknowledged to be the rate-limiting determinant of telomerase, and transcriptional regulation of the TERT gene plays a key role in the activation of telomerase. Hamster and human TERT promoters share common protein binding sites, such as E-boxes or GC-boxes, which are for Myc and Spl, respectively. Recent studies have demonstrated that expression of human TERT (hTERT) is usually affected by Spl, but not by c-Myc.<BR>To study the effect of transcriptional factor Spl on the transactivation of TERT, we investigated the expression of Spl and TERT mRNAs by RT PCR during carcinogenesis of the hamster tongue induced by DMBA. We attempted to gain insight into the relation between the expression of these factors.<BR>The expression of hamster TERT mRNA strongly correlated with telomerase activity. Coincidentally, we found that the expression of Spl and hamster TERT were upregulated in dysplasia and squamous cell carcinoma tissues and were closely linked to each other. These results suggest that Spl is a crucial regulatory factor for hamster TERT transactivation during carcinogenesis of the tongue.
Journal
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- Japanese Journal of Oral and Maxillofacial Surgery
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Japanese Journal of Oral and Maxillofacial Surgery 51 (7), 324-331, 2005
Japanese Society of Oral and Maxillofacial Surgeons
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Details 詳細情報について
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- CRID
- 1390282681507557504
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- NII Article ID
- 10018954758
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- NII Book ID
- AN00189163
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- ISSN
- 21861579
- 00215163
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- NDL BIB ID
- 7431438
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed