A case of systemic amyloidosis with swelling in the tongue and submandibular region as an initial symptom

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  • KIMURA Yoshihiro
    Division of Surgery 2, Department of Dentistry and Oral Surgery, Osaka Medical College
  • SHIMAHARA Masashi
    Division of Surgery 2, Department of Dentistry and Oral Surgery, Osaka Medical College
  • HASHIGUCHI Norihiro
    Division of Surgery 2, Department of Dentistry and Oral Surgery, Osaka Medical College
  • NAKAJIMA Yoichiro
    Division of Surgery 2, Department of Dentistry and Oral Surgery, Osaka Medical College
  • SHIMAHARA Takeshi
    Division of Surgery 2, Department of Dentistry and Oral Surgery, Osaka Medical College
  • FUJITA Hiroshi
    Division of Surgery 2, Department of Dentistry and Oral Surgery, Osaka Medical College

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Other Title
  • 舌および顎下部の腫脹を契機に発見された全身性アミロイドーシスの1例
  • シタ オヨビ ガクカブ ノ シュチョウ オ ケイキ ニ ハッケンサレタ ゼンシンセイ アミロイドーシス ノ 1レイ

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Abstract

Amyloidosis is caused by amyloid substance deposition in various organs and tissues of the body. A case of systemic amyloidosis with swelling in the tongue and submandibular region as an initial symptom is reported. A 63-year-old man presented with swelling of the tongue and submandibular region. Detailed clinical examinations and biopsy were performed. There were no signs suggesting a malignant tumor. Subsequently, purpura of the lips and induration of the lower lip and buccal mucosa appeared. Chest radiographic examination revealed cardiac hypertrophy and pleural fluid. Systemic amyloidosis was suspected. A biopsy specimen taken from the buccal mucosa revealed deposition of amyloid. Congo-red stain for amyloid was positive. Systemic amyloidosis was diagnosed. The patient was followed up in the department of internal medicine. After 14 months, the patient died of cardiac failure due to amyloid deposition.

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