2次元NMR法で決定したEGFの立体構造

  • 神田 大輔
    東京都臨床医学総合研究所生理活性物質研究部門

書誌事項

タイトル別名
  • Three-dimensional structure of mouse epidermal growth factor determined by two-dimensional NMR.
  • 2ジゲン NMR デ ケッテイシタ EGF ノ リッタイ コウゾウ

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抄録

The three-dimensional structures of mouse epidermal growth factor (53 residues) in pH 2.1 and pH 6.8 solutions were determined by two-dimensional NMR and distance geometry calculation. Ten structures that satisfied the NMR-derived distance constraints were obtained for each pHs using XPLOR program. The topology of the main chain was identical at both pHs, but the global shape at pH 6.8 was found to be more compact than that at pH 2.1.

収録刊行物

  • 生物物理

    生物物理 30 (3), 107-112, 1990

    一般社団法人 日本生物物理学会

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