A case of Langerhans cell histiocytosis of the mandible treated by intralesional injection of corticosteroids

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  • NAKAYA Michiko
    Department of Oral and Maxillofacial Surgery Kochi Medical School, Kochi University
  • NARIKAWA Gen
    Department of Oral and Maxillofacial Surgery Kochi Medical School, Kochi University
  • NAKAMURA Yuichiro
    Department of Oral and Maxillofacial Surgery Kochi Medical School, Kochi University
  • KITAMURA Naoya
    Department of Oral and Maxillofacial Surgery Kochi Medical School, Kochi University
  • YAMADA Tomohiro
    Department of Oral and Maxillofacial Surgery Kochi Medical School, Kochi University
  • YAMAMOTO Tetsuya
    Department of Oral and Maxillofacial Surgery Kochi Medical School, Kochi University

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Other Title
  • コルチコステロイドの局所注射が奏効した下顎骨ランゲルハンス細胞組織球症の1例
  • コルチコステロイド ノ キョクショ チュウシャ ガ ソウコウ シタ カガクコツ ランゲルハンス サイボウ ソシキキュウショウ ノ 1レイ

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We report a case of Langerhans cell histiocytosis （LCH） of the mandible that was treated by intralesional injection of corticosteroids. A 57-year-old man was referred to our clinic because of gingival swelling and tenderness around the left molar region of the mandible. Computed tomography revealed a relatively well-defined bone defect and a pathologic fracture in the left body of the mandible. An excisional biopsy was performed, and the lesion was histopathologically diagnosed as LCH. Since the patient refused surgical excision, intralesional injection of corticosteroids was performed. The lesion and the pathologic fracture became undetectable 5 months after the administration of 40mg dexamethasone. There was no recurrence after a follow-up period of 1 year 5 months. Intralesional injection of corticosteroid may be one beneficial option for the treatment of LCH of the mandible.

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