書誌事項
- タイトル別名
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- A case of intraoral methotrexate-assosiated lymphoproliferative disorder
- コウクウ ナイ メトトレキサート カンレン リンパ ゾウショクセイ シッカン ノ 1レイ
- A case of intraoral methotrexate-associated lymphoproliferative disorder
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説明
Methotrexate (MTX) has been used not only for cancer and leukemia therapy, but also for the treatment of rheumatoid arthritis (RA). However, some reports caution that MTX might induce MTX-associated limphoproliferative disorders (MTX-LPD). We report a case of MTX-LPD associated with a gingival ulcer, which led to the diagnosis. A 66-year-old woman was referred to our hospital because of a chronic gingival nlcer of the maxilla. She had been receiving predonisolone (PSL) and MTX for over 12 years to treat RA. She had noticed an upper gingival ulcer 2 months before presentation, which gradually increased in size. Computed tomography showed bone resorption in the anterior region of the maxilla. Reported pathological examination revealed diffuse large B-cell lymphoma and immunohistochemistry supported the diagnosis of MTX-LPD. After stopping MTX,removing the necrotic bone, and antibacterial chemotherapy, the ulcer spontaneously resolved.
収録刊行物
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- 日本口腔外科学会雑誌
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日本口腔外科学会雑誌 57 (3), 104-108, 2011
社団法人 日本口腔外科学会
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詳細情報 詳細情報について
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- CRID
- 1390282681507735168
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- NII論文ID
- 10030271573
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- NII書誌ID
- AN00189163
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- ISSN
- 21861579
- 00215163
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- NDL書誌ID
- 11051911
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可