Cure of a case of osteonecrosis of the mandible associated with an oral bisphosphonate

YAMASHITA Tomomi, MATSUMOTO Yuhki, ASAKA Yuichiro, MAKITA Hiroki, TOIDA Makoto, SHIBATA Toshiyuki

doi:10.5794/jjoms.54.243

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Other Title

経口ビスフォスフォネート製剤に関連した下顎骨壊死の治癒経験
ケイコウビスフォスフォネートセイザイニカンレンシタカガクコツエシノチユケイケン

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We report a case of osteonecrosis of the mandible associated with an oral bisphosphonate (BP) in apatient with osteoporosis and describe its cure.<BR>A 84-year-old woman received oral alendronate sodium hydrate from September 2004 through April 2006. Shewas referred to our department because of a fistula that developed after extraction of the lower right first and secondpremolars in April 2006 by her dentist. Physical examination revealed diffuse swelling of the right mandible, and hypoesthesia was present in the right mental region. Imaging of the lesion revealed an extensive radiolucentarea and a tumor-like mass in the right side of the mandible. Antibiotic therapy was started, and initial biopsy andexcisional biopsy were carried out to rule out malignant lesions. Histopathological examination showed granulationtissue and bone necrosis. BP-associated osteonecrosis of the jaw was diagnosed. BP medication was withdrawn, and conservative therapy was performed. Cure of the lesion, including bone regeneration, was observed 1year later.

Journal

Japanese Journal of Oral and Maxillofacial Surgery

Japanese Journal of Oral and Maxillofacial Surgery 54 (4), 243-247, 2008

Japanese Society of Oral and Maxillofacial Surgeons

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