A case of methotrexate-associated lymphoproliferative disorders arising in the maxilla in a patient with juvenile idiopathic arthritis in adulthood
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- UEHARA Shinobu
- Department of Dentistry and Oral Surgery, Suwa Central Hospital
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- OKUBO Hiroki
- Department of Dentistry and Oral Surgery, Suwa Central Hospital
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- NANRI Tadayuki
- Department of Dentistry, Kakeyu Hospital
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- KOIKE Takeshi
- Department of Dentistry and Oral Surgery, Shinshu University School of Medicine
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- KAMATA Takahiro
- Department of Dentistry and Oral Surgery, Shinshu University School of Medicine
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- KURITA Hiroshi
- Department of Dentistry and Oral Surgery, Shinshu University School of Medicine
Bibliographic Information
- Other Title
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- 成人期若年性特発性関節炎患者の上顎に発生したメトトレキサート関連リンパ増殖性疾患の1例
- セイジンキ ジャクネンセイ トクハツセイ カンセツエン カンジャ ノ ウワアゴ ニ ハッセイ シタ メトトレキサート カンレン リンパ ゾウショクセイ シッカン ノ 1レイ
- A case of methotrexate-associated lymphoproliferative disorders in the maxilla in a patient with juvenile idiopathic arthritis in adulthood
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Abstract
Methotrexate (MTX) is a key drug widely used to treat rheumatoid arthritis. However, several reports have recently described cases of MTX-associated lymphoproliferative disorders (MTX-LPD). We report a case of MTX-LPD arising in the maxilla of a patient with juvenile idiopathic arthritis in adulthood.<br>A 40-year-old woman was referred to our clinic for the treatment of pain in the anterior maxillary gingiva. She had had juvenile idiopathic arthritis in adulthood and had received MTX for 4 years. On clinical examination, a swelling was noted at the incisal region of the maxilla. CT imaging showed a diffuse bone defect around the roots of the maxillary incisors. Antibiotic therapy had no effect on the lesion, and a biopsy was carried out. The histopathological diagnosis was diffuse large B cell lymphoma. After discussion with her physician, we suspected MTX-LPD and directed her to stop taking MTX. After stopping MTX, the lesion disappeared.
Journal
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- Japanese Journal of Oral and Maxillofacial Surgery
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Japanese Journal of Oral and Maxillofacial Surgery 58 (9), 550-554, 2012
Japanese Society of Oral and Maxillofacial Surgeons
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Details 詳細情報について
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- CRID
- 1390282681508344320
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- NII Article ID
- 10031144939
- 130004707925
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- NII Book ID
- AN00189163
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- ISSN
- 21861579
- 00215163
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- NDL BIB ID
- 024020023
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed