A case of post-transplantation lymphoproliferative disorder (PTLD) of the oral mucosa after human bone marrow transplantation

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  • SAIJO Hideto
    Department of Oral-maxillofacial Surgery Dentistry and Orthodontics, The University of Tokyo Hospital
  • MORI Yoshiyuki
    Department of Oral-maxillofacial Surgery Dentistry and Orthodontics, The University of Tokyo Hospital
  • CHIKAZU Daichi
    Department of Oral-maxillofacial Surgery Dentistry and Orthodontics, The University of Tokyo Hospital
  • FUJIHARA Hisako
    Department of Oral-maxillofacial Surgery Dentistry and Orthodontics, The University of Tokyo Hospital
  • YONEHARA Yoshiyuki
    Department of Oral-maxillofacial Surgery Dentistry and Orthodontics, The University of Tokyo Hospital
  • TAKATO Tsuyoshi
    Department of Oral-maxillofacial Surgery Dentistry and Orthodontics, The University of Tokyo Hospital

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Other Title
  • 骨髄移植後に口腔粘膜にみられた移植後リンパ球増殖症の１例
  • ショウレイ ホウコク コツズイ イショク ゴ ニ コウクウ ネンマク ニ ミラレタ イショク ゴ リンパキュウ ゾウショクショウ ノ 1レイ

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A 20-year-old man was referred to our department because of severe pain while eating. Physical examination revealed an erosion and ulcer in the oral cavity. He had been treated for aplastic anemia on an outpatient basis at the Department of Cell Therapy and Transplantation Medicine of our hospital. He had received bone marrow transplants twice. Subsequently, graft-versus-host disease (GVHD) developed, and treatment with cyclosporine was started. Biopsy ruled out the possibility that the lesion in the oral cavity was caused by GVHD. Gingival hyperplasia was noted 8 months later, and granulomatous epulis was diagnosed. The patient's general condition subsequently deteriorated, and mucosal proliferation spread throughout the oral cavity. Biopsy yielded a diagnosis of post-transplantation lymphoproliferative disorder (PTLD). We describe our experience with this rare case of PTLD.

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