口蓋粘膜小腫瘤を契機に発見された腎細胞癌の1例

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  • A case of renal cell carcinoma diagnosed in association with a palatal mucosa mass
  • コウガイ ネンマク ショウシュリュウ オ ケイキ ニ ハッケン サレタ ジンサイボウガン ノ 1レイ

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Approximately 1% to 3% of malignant oral tumors are metastatic tumors from primary tumors arising in organs such as the lungs, stomach, and liver. In particular, renal cell carcinoma (RCC) rarely metastasizes to the oral and maxillofacial region. We report a case of metastatic RCC that initially presented as a tumor of the palatal mucosa. The patient was a 56-year-old man who visited our department because of a small tumor of the palatal mucosa. An excisional biopsy of the tumor suggested a metastasis from clear cell RCC. Further examinations revealed that the primary site was the left kidney. RCC with metastases to the lung, left adrenal gland, and left femur was also detected. The patient underwent nephrectomy, adrenalectomy, and radiotherapy for left thigh bone metastasis in the Department of Urology. He is now receiving molecular targeted therapy with axitinib and is given denosumab approximately every 4weeks for left thigh bone metastasis. Three years have passed since resection of the tumor in the palatal mucosa. There has been no recurrence at the primary lesion site or elsewhere in the oral cavity, and the other metastatic lesions are well controlled.

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