A case of hybrid peripheral nerve sheath tumor of the tongue

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  • MURATA Satoko
    Department of Oral and Maxillofacial Surgery, Kochi Medical School, Kochi University
  • SENTOU Shinya
    Department of Oral and Maxillofacial Surgery, Kochi Medical School, Kochi University
  • SASABE Eri
    Department of Oral and Maxillofacial Surgery, Kochi Medical School, Kochi University
  • KITAMURA Naoya
    Department of Oral and Maxillofacial Surgery, Kochi Medical School, Kochi University
  • HIROI Makoto
    Laboratory of Diagnostic Pathology, Kochi Medical School Hospital, Kochi University
  • YAMAMOTO Tetsuya
    Department of Oral and Maxillofacial Surgery, Kochi Medical School, Kochi University

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  • 舌に発生したHybrid peripheral nerve sheath tumor の1例
  • シタ ニ ハッセイ シタ Hybrid peripheral nerve sheath tumor ノ 1レイ

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Hybrid peripheral nerve sheath tumors（PNSTs） are tumors in which more than one characteristic structure of schwannoma, neurofibroma, and perineurioma occurs within a single lesion. Although hybrid PNSTs have recently been described, with the great majority arising in peripheral nerves of the trunk and extremities, there are few reports on hybrid PNST in the oral cavity. We describe a case of hybrid PNST arising in the tongue. A 40-year-old woman was referred to our hospital because of a painless mass on the left margin of the tongue. The mass was 15 mm in diameter and well circumscribed. We performed an excisional biopsy for a clinical diagnosis of a benign tumor. Histopathologically, the tumor showed a palisading-like sequence typical of schwannomas, whereas spindle cells with delicate processes were arranged in a parallel fashion and showed the histopathological characteristics of perineuriomas. Immunohistochemical analysis showed that the tumor cells were positive for both S-100 protein and epithelial membrane antigen. Therefore, we diagnosed this case to be hybrid PNST（hybrid schwannoma/perineurioma）. The postoperative course has been uneventful, with no recurrence for approximately 2 years.

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