Genetic systems for stability of DNA.

DOI Web Site Web Site 9 References

Bibliographic Information

Other Title
  • ＤＮＡの安定性を維持する遺伝子群と細胞の癌化
  • DNA ノ アンテイセイ オ イジスル イデンシグン ト サイボウ ノ ガンカ

Search this article

Abstract

The frequency of errors during a single cycle of DNA replication is less than 10-10per base pair. This high accuracy is ascribed to three independent steps of DNA replication; base selection by DNA polymerase, elimination of mismatched nucleotide by proofreading exonuclease and post-replication mismatch repair. In addition, elimination of mutagenic substrate from the precursor pool and repair of damaged DNA template are involved. Defect in any one of genes controlling the above mentioned steps would cause high frequency of spontaneous mutation. Significance of genetic instablility in carcinogenesis is discussed, with special reference to hereditary cancer.

Journal

  • Seibutsu Butsuri

    Seibutsu Butsuri 37 (3), 100-105, 1997

    The Biophysical Society of Japan General Incorporated Association

References(9)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top