Changes in the expression of sarcoendoplasmic reticulum Ca2+ ATPase type 2 in lower gingival squamous cell carcinomas

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  • SHIIBA Masashi
    Department of Dentistry and Oral-Maxillofacial Surgery, Chiba University Hospital
  • ENDO Yosuke
    Department of Dentistry and Oral-Maxillofacial Surgery, Chiba University Hospital
  • UESUGI Hisako
    Department of Dentistry and Oral-Maxillofacial Surgery, Chiba University Hospital
  • KAWASAKI Kenshi
    Department of Dentistry and Oral-Maxillofacial Surgery, Chiba University Hospital
  • ONO Kanae
    Department of Dentistry and Oral-Maxillofacial Surgery, Chiba University Hospital
  • MURANO Akiyuki
    Department of Dentistry and Oral-Maxillofacial Surgery, Chiba University Hospital
  • HAYASHI Yukio
    Department of Dentistry and Oral-Maxillofacial Surgery, Chiba University Hospital
  • OGAWARA Katsunori
    Department of Dentistry and Oral-Maxillofacial Surgery, Chiba University Hospital
  • UZAWA Katsuhiro
    Department of Dentistry and Oral-Maxillofacial Surgery, Chiba University Hospital
  • TANZAWA Hideki
    Department of Dentistry and Oral-Maxillofacial Surgery, Chiba University Hospital

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Other Title
  • 下顎歯肉へん平上皮癌におけるＳａｒｃｏｅｎｄｏｐｌａｓｍｉｃ　Ｒｅｔｉｃｕｌｕｍ　Ｃａ｀２＋´　ＡＴＰａｓｅ　Ｔｙｐｅ　２の発現の変化
  • カガク シニク ヘンペイ ジョウヒガン ニ オケル Sarcoendoplasmic Reticulum Ca 2 ATPase Type 2 ノ ハツゲン ノ ヘンカ

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Abstract

Sarcoendoplasmic reticulum calcium transport ATPases (SERCAs) accumulate Ca2+in the endoplasmic reticulum and are essential molecules in calcium-mediated signaling. Some reports indicate that down-regulation of these enzymes is closely associated with carcinogenesis. We thus hypothesized that the ATP2A2 gene, coding SERCA 2 protein, may be associated with oral carcinogenesis. Forty lower gingival squamous cell carcinomas (SCCs), 20 gingival premalignant lesions (leukoplakias), and adjacent normal tissue samples were examined. Immunohistochemical studies revealed strong expression of SERCA2 protein in all normal tissues and significantly down-regulated expression of SERCA2 protein in 45% of SCCs. Expression of SERCA2 in the premalignant lesions tended to decrease, but was higher than that in SCCs. Moreover, analyses according to clinical and pathological classifications indicated that the decreased SERCA2 protein expression in lower gingival SCCs correlated with the progression of carcinogenesis and the extent of malignancy. These results suggested that ATP2A2 gene expression might be altered in relation to the clinical profiles of lower gingival SCCs.

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