書誌事項
- タイトル別名
-
- Changes in the expression of sarcoendoplasmic reticulum Ca2+ ATPase type 2 in lower gingival squamous cell carcinomas
- カガク シニク ヘンペイ ジョウヒガン ニ オケル Sarcoendoplasmic Reticulum Ca 2 ATPase Type 2 ノ ハツゲン ノ ヘンカ
この論文をさがす
抄録
Sarcoendoplasmic reticulum calcium transport ATPases (SERCAs) accumulate Ca2+in the endoplasmic reticulum and are essential molecules in calcium-mediated signaling. Some reports indicate that down-regulation of these enzymes is closely associated with carcinogenesis. We thus hypothesized that the ATP2A2 gene, coding SERCA 2 protein, may be associated with oral carcinogenesis. Forty lower gingival squamous cell carcinomas (SCCs), 20 gingival premalignant lesions (leukoplakias), and adjacent normal tissue samples were examined. Immunohistochemical studies revealed strong expression of SERCA2 protein in all normal tissues and significantly down-regulated expression of SERCA2 protein in 45% of SCCs. Expression of SERCA2 in the premalignant lesions tended to decrease, but was higher than that in SCCs. Moreover, analyses according to clinical and pathological classifications indicated that the decreased SERCA2 protein expression in lower gingival SCCs correlated with the progression of carcinogenesis and the extent of malignancy. These results suggested that ATP2A2 gene expression might be altered in relation to the clinical profiles of lower gingival SCCs.
収録刊行物
-
- 日本口腔外科学会雑誌
-
日本口腔外科学会雑誌 51 (4), 154-160, 2005
社団法人 日本口腔外科学会
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1390282681508806016
-
- NII論文ID
- 10019220817
-
- NII書誌ID
- AN00189163
-
- ISSN
- 21861579
- 00215163
-
- NDL書誌ID
- 7332056
-
- 本文言語コード
- ja
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可