書誌事項
- タイトル別名
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- Involvement of decreased expression of KAI1 in carcinogenesis and lymph node metastasis of lower gingival squamous cell carcinomas
- カガク シニク ヘンペイ ジョウヒガン ノ ハッセイ ト リンパセツ テンイ ニ オケル KAI1 イデンシ ハツゲン ゲン ジャク ノ カンヨ
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KAI1is a tumor suppressor gene originally identified in prostate cancer. Recent studies of oral cancer, including our investigations, have shown frequent down-regulation ofKAI1expression in many tumor types, whereas mutation of the gene is infrequent. However, the role of the down-expression ofKAI1in oncogenesis and the progression of oral carcinoma remains unclear. In this study, we analyzed the mutational status of KAI1and both the mRNA and protein levels of the gene in a series of gingival carcinomas and precancerous lesions (20 leukoplakias, 50 squamous cell carcinomas, and 20 lymph node metastatic tumors). Although no mutation was found in any sample tested, immunohistochemical studies revealed high frequencies of KAI1 down-regulation not only in the metastatic tumors (20 of 20, 100 %), but also in the primary carcinomas (39 of 50, 78 %) and leukoplakias (9 of 20, 45 %). Down-regulation of KAI1 protein expression was significantly related to carcinogenesis and metastasis (precancerous lesions, primary carcinomas, and metastatic tumors)(p<0.001) as well as to lymph node metastasis (p=0.0022). RT PCR analysis confirmed these results. Therefore, suppressed expression ofKAI1was suggested to play clinically significant roles in carcinogenesis and lymph node metastasis.
収録刊行物
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- 日本口腔外科学会雑誌
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日本口腔外科学会雑誌 51 (4), 166-171, 2005
社団法人 日本口腔外科学会
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詳細情報 詳細情報について
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- CRID
- 1390282681508811264
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- NII論文ID
- 10019220855
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- NII書誌ID
- AN00189163
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- ISSN
- 21861579
- 00215163
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- NDL書誌ID
- 7332099
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 使用不可