A case of central mucoepidermoid carcinoma of the maxilla in an 18-year-old male patient

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  • KUROSHIMA Takeshi
    Oral Diagnosis and medicine, Division of Oral Pathobiological Science, Graduate School of Dental Medicine, Hokkaido University Department of Dentistry and Oral Surgery, Hokuto Hospital
  • SATO Takehiko
    Department of Dentistry and Oral Surgery, Hokuto Hospital
  • TAKANO Masashi
    Department of Dentistry and Oral Surgery, Hokuto Hospital
  • SHINDOH Masanobu
    Oral Pathology and Biology, Division of Oral Pathobiological Science, Graduate School of Dental Medicine, Hokkaido University
  • MAKINO Shujiroh
    Department of Dentistry and Oral Surgery, Hokuto Hospital
  • KITAGAWA Yoshimasa
    Oral Diagnosis and medicine, Division of Oral Pathobiological Science, Graduate School of Dental Medicine, Hokkaido University

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  • 18歳男性に発生した上顎骨中心性と考えられた粘表皮癌の1例
  • 18サイ ダンセイ ニ ハッセイ シタ ジョウガクコツ チュウシンセイ ト カンガエラレタ ネンヒョウヒガン ノ 1レイ

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Abstract

Central Mucoepidermoid carcinoma (cMEC) is uncommon entity and occurs commonly in the mandible, but rarely in the maxilla. Furthermore, the occurrence of cMEC in children and adolescents is extremely rare. An 18-year-old male patient was referred to our hospital because of halitosis and fistula of the palate. Radiological examination showed a cystic lesion in the right side of the maxilla with bone destruction. The histopathological diagnosis on biopsy was MEC. Partial maxillectomy was successfully performed. There has been no evidence of recurrence or metastasis as of 3 years after the operation. Real-time RT-PCR assay of paraffin-embedded tissue showed positivity of MEC-specific CRTC1-MAML2 gene fusions, suggesting a good prognosis.

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