Molecular Mechanism of Kinesin Motor.

  • KAWAGUCHI Kenji
    Department of Physics, School of Science & Engineering, Waseda University
  • UEMURA Sotaro
    Department of Physics, School of Science & Engineering, Waseda University
  • ISHIWATA Shin'ichi
    Department of Physics, School of Science & Engineering, Waseda University

Bibliographic Information

Other Title
  • キネシン分子モーターの仕組み
  • 解説 キネシン分子モーターの仕組み
  • カイセツ キネシン ブンシ モーター ノ シクミ

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Abstract

Kinesin motors are mechano-enzymes that hydrolyze ATP to generate force and directional movement along a microtubule. Nucleotide-dependent conformational changes of the head and neck region of kinesin have been shown by cryoelectron microscopy and spectroscopic techniques. Single molecule analysis supports key predictions of the hand-over-hand model for motility of dimeric conventional kinesin, whereas the discovery of a processive one-headed kinesin strongly supports the biased Brownian ratchet model. In this short review, we summarize the present status of research on the mechanism of kinesin motility.

Journal

  • Seibutsu Butsuri

    Seibutsu Butsuri 42 (4), 156-161, 2002

    The Biophysical Society of Japan General Incorporated Association

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