A Novel Approach to the Problems on Protein Evolution.

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  • OTSUKA Jinya
    Department of Applied Biological Science, Faculty of Science and Technology
  • HORIMOTO Katsuhisa
    Research Institute for Biosciences, Science University of Tokyo

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Other Title
  • 蛋白質進化の問題への新しいアプローチ
  • タンパクシツ シンカ ノ モンダイ エ ノ アタラシイ アプローチ

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Abstract

Instead of the enumeration of amino acid changes in the usual studies of protein evolution, a novel approach is proposed to investigate the amino acid changes focusing on the properties of changed residues. This is illustrated by two analyses: one is the discrimination between adaptive changes and neutrat ones and another is the principal component analysis to assign similar region (s) of the proteins, which seem to be distantly related but cannot be easily detected by the usual similarity search. Throughout these analyses, concrete evidences are provided for divergence pattern and selective mode in amino acid changes, connecting some of the changes with functional changes.

Journal

  • Seibutsu Butsuri

    Seibutsu Butsuri 34 (1), 18-24, 1994

    The Biophysical Society of Japan General Incorporated Association

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